林产化学与工业 ›› 2022, Vol. 42 ›› Issue (6): 136-146.doi: 10.3969/j.issn.0253-2417.2022.06.018
• 综述评论 • 上一篇
李文君1,2, 王成章1,*(), 雷建都2, 唐凤霞1,2, 裴东3, 宋晓波3
收稿日期:
2021-08-26
出版日期:
2022-12-28
发布日期:
2023-01-07
通讯作者:
王成章
E-mail:wangczlhs@sina.com
作者简介:
王成章, 研究员, 博士生导师, 研究领域为天然植物资源加工与利用;E-mail:wangczlhs@sina.com基金资助:
Wenjun LI1,2, Chengzhang WANG1,*(), Jiandu LEI2, Fengxia TANG1,2, Dong PEI3, Xiaobo SONG3
Received:
2021-08-26
Online:
2022-12-28
Published:
2023-01-07
Contact:
Chengzhang WANG
E-mail:wangczlhs@sina.com
摘要:
Oleocanthal(OC)是橄榄油的次生代谢产物, 是目前国外研究热点, 而国内关注较少, 相关研究基础薄弱, 与国外差距明显。作为近年来发现的重要活性物质, OC具有比布洛芬更强的抗炎活性, 对以炎症为起源的多种疾病具有预防和治疗作用, 如风湿类疾病、癌症、心血管疾病、糖尿病等, 同时其神经保护功能也促使OC可以抑制阿尔茨海默症和帕金森症等神经退行性疾病的发生。本综述重点对OC的抗炎活性、抗癌活性(包括黑色素瘤、多发性骨髓瘤、乳腺癌和结肠癌)、神经保护、心血管保护、糖尿病的预防和治疗作用等生物活性进行了深入介绍,也分析了当前比较高效的OC提取分离方法, 包括液-液萃取分离法、高效逆流色谱提取法、高真空辅助提取法和离心分配色谱法, 同时对影响OC含量的多种因素进行了综合讨论, 并进一步探讨了OC在生物利用度方面的研究进展, 最后对OC的未来研究进行了展望。
中图分类号:
李文君, 王成章, 雷建都, 唐凤霞, 裴东, 宋晓波. 橄榄油次生代谢产物oleocanthal的研究进展[J]. 林产化学与工业, 2022, 42(6): 136-146.
Wenjun LI, Chengzhang WANG, Jiandu LEI, Fengxia TANG, Dong PEI, Xiaobo SONG. Research Progress on Olive Oil Secondary Metabolite of Oleocanthal[J]. Chemistry and Industry of Forest Products, 2022, 42(6): 136-146.
图1
橄榄油总多酚提取物中分离的化合物[19] 1.2-(4-羟基苯基)乙基(E)-4-甲酰基-3-(2-氧代乙基)己基-4-烯酸酯oleocanthal;2.2-(3, 4-二羟基苯基)乙基(Z)-4-甲酰基-3-(2-氧代乙基)己基-4-烯酸酯oleacein;3.羟基酪醇hydroxytyrosol;4.酪醇tyrosol;5.β-谷甾醇β-sitosterol;6.齐墩果酸oleanolic acid;7.山楂酸maslinic acid;8.皂苷苷元(5S, 8R, 9S)和(5S, 8S, 9S)的单醛形式monoaldehydic form of ligstroside aglycon(MFLA), MFLA(5S, 8R, 9S) and (5S, 8S, 9S);9.橄榄苦苷苷元(5S, 8R, 9S)和(5S, 8S, 9S)的单醛形式monoaldehydic form of oleuropein aglycon(MFDA), MFOA(5S, 8R, 9S) and (5S, 8S, 9S);10.1-乙酰氧基松脂醇1-acetoxypinoresinol;11.烯醇酸(5S, 8R, 9S)和(5S, 8S, 9S)elenolic acid(5S, 8R, 9S) and (5S, 8S, 9S);12.烯醇酸甲酯(5S, 8R, 9S)和(5S, 8S, 9S)elenolic acid methylester(5S, 8R, 9S) and (5S, 8S, 9S);13.烯醇酸乙酯(5S, 8R, 9S)和(5S, 8S, 9S) elenolic acid ethylester(5S, 8R, 9S) and (5S, 8S, 9S);14.脱羧甲基烯醇酸的二醛形式dialdehydic form of decarboximethyl elenolic acid(EDA)"
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