胡椒乙酸的合成

林产化学与工业 ›› 2002, Vol. 22 ›› Issue (04): 80-82.

胡椒乙酸的合成

周灵君¹, 贺全国², 刘正春², 杨春¹, 何农跃²

1. 南京师范大学, 化学与环境科学学院, 江苏, 南京, 210097;2. 东南大学, 分子与生物分子电子学实验室, 江苏, 南京, 210096

收稿日期:2002-05-27 修回日期:1900-01-01 出版日期:2002-12-30 发布日期:2002-12-30

SYNTHESIS OF 1,3-BENZODIOXOLE-5-ACETIC ACID

ZHOU Ling-jun¹, HE Quan-guo², LIU Zheng-chun², YANG Chun¹, HE Nong-yue²

1. College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China;2. Key Lab for Molecular and Biomolecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China

Received:2002-05-27 Revised:1900-01-01 Online:2002-12-30 Published:2002-12-30

摘要/Abstract

摘要： 从邻苯二酚出发,合成胡椒基环后直接氯甲基化,再经腈化、水解合成了胡椒乙酸,总收率达54.2%,对各产物进行了气相色谱、红外光谱测定及元素分析。

关键词: 邻苯二酚, 胡椒乙酸

Abstract: 1,3-Benzodioxole-5-acetic acid was synthesized from 1,2-benzenediol in a four step procedure.1,2-Benzenediol reacted with dichloromethane to give 1,3-benzodioxole,which was directly chloromethylated to yield 90.1% 5-chloromethyl 1,3-benzodioxole.The chloride was converted easily to 3,4-methlenedioxyphenyl acetonitrile by 80% yield under sodium cyanide nitrilation,followed by alkali hydrolysis to give 1,3-benzodioxole-5-acetic acid.Total yield was 54.2%.Gas chromatography,infrared spectra and elemental analysis were used for characterizations.

Key words: 2-benzenediol, 3-benzodioxole-5-acetic acid

中图分类号:

O625.511

周灵君;贺全国;刘正春;杨春;何农跃. 胡椒乙酸的合成[J]. 林产化学与工业, 2002, 22(04): 80-82.

ZHOU Ling-jun;HE Quan-guo;LIU Zheng-chun;YANG Chun;HE Nong-yue. SYNTHESIS OF 1,3-BENZODIOXOLE-5-ACETIC ACID[J]. , 2002, 22(04): 80-82.

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