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林产化学与工业

林产化学与工业 ›› 2007, Vol. 27 ›› Issue (S1): 24-28.

• 研究报告 • 上一篇    下一篇

银杏叶聚戊烯醇对荷瘤鼠生命延长率的研究

王成章, 沈兆邦, 郑光耀, 叶建中, 周昊   

  1. 中国林业科学研究院 林产化学工业研究所;国家林业局 林产化学工程重点开放性实验室, 江苏 南京 210042
  • 收稿日期:2007-06-20 修回日期:1900-01-01 出版日期:2007-10-20 发布日期:2007-10-20

Study on Effect of Polyprenols from Ginkgo biloba Linn. on Prolonging the Life of Cancer-bearing Mice

WANG Cheng-zhang, SHEN Zhao-bang, ZHENG Guang-yao, YE Jian-zhong, ZHOU Hao   

  1. Institute of Chemical Industry of Forest Products, CAF;Key and Open Lab.on Forest Chemical Engineering, SFA, Nanjing 210042, China
  • Received:2007-06-20 Revised:1900-01-01 Online:2007-10-20 Published:2007-10-20

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摘要： 以银杏叶为原料,采用皂化反应、溶剂冷冻和Ⅱ级分子蒸馏分离聚戊烯醇不皂化物,精制银杏叶聚戊烯醇(GP),纯度87.3%.通过建立人脑瘤SF763、人肺腺瘤A549和艾氏腹水瘤EC移植小鼠模型,GP口服给药,研究GP对人脑瘤SF763裸鼠和艾氏腹水瘤EC小鼠的生命延长率,观察GP对人肺腺瘤A549裸鼠的抑瘤率.结果表明:生药剂量320 mg/kg GP联合2 mg/kg阿霉素(ADM),其生命延长率为88%(P<0.01),GP能明显延长荷人脑瘤SF763裸鼠生命;GP在大于40 mg/kg时对人肺腺瘤A549裸鼠具有明显的抑制作用(P<0.05),最佳剂量为GP80 mg/kg,接种时间11 d,抑瘤率为82.2%(P<0.01);GP对艾氏腹水瘤EC小鼠的生存期呈现负量效关系,GP最佳剂量范围在5～10 mg/kg,最高生命延长率为32.77%(P<0.05).

关键词: 银杏叶, 聚戊烯醇, 人脑瘤SF763, 人肺腺瘤A549, 艾氏腹水瘤EC, 生命延长率

Abstract: Polyprenols from Ginkgo biloba Linn. (GP) was made to get a purify of 87.3% by separating non-saponifialble matter of GP with means of saponification, solvent refrigeration and II-grade molecular distillation. Different models of mice planted with SF763 tumor, A549 tumor, and transplanted EC tumor respectively were built. The effects of GP on prolonging survival time of mice bearing tumors of SF763, A549 and Ec respectively were studied by treating with ADM and ACNU iv., CY ip.and polyprenols po..The results showed that GP(320 mg/kg) combined with ADM(2 mg/kg) could significantly prolong survival time of mice bearing SF763 tumor, the life-prolonging rate was 88% (P<0.01)in contrast to normal controls; GP (>40 mg/kg) significantly had a inhibition on A549(P<0.05), the optium dosage of GP was 80 mg/kg, which had an inhibition of 82.2%(P<0.01) after an inoculation of 11 days; GP had a negative relation on prolonging survival time of mice bearing EC tumors between dosage of GP and the effect. The optimum dosage was 5-10 mg/kg,which had optimum prolonging rate of 32.77%(P<0.05). Thus GP could significantly prolong survival time of mice bearing SF763, A549 and EC tumors.

Key words: Ginkgo biloba Linn., polyprenols, SF763, A549, EC, life-prolonging rate

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