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林产化学与工业

林产化学与工业 ›› 2011, Vol. 31 ›› Issue (5): 1-5.

• 研究报告 •    下一篇

丙烯海松双酰基硫脲衍生物的合成及抑菌活性研究

李健1, 饶小平1,2, 商士斌1,2,3, 高艳清1   

  1. 1. 中国林业科学研究院 林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局 林产化学工程重点开放性实验室;江苏省生物质能源与材料重点实验室, 江苏 南京 210042;2. 中国林业科学研究院 林业新技术研究所, 北京 100091;3. 江苏强林生物能源有限公司, 江苏 溧阳 213364
  • 收稿日期:2011-02-15 修回日期:1900-01-01 出版日期:2011-10-30 发布日期:2011-10-30
  • 通讯作者: 商士斌,男,博士生导师,研究领域:生物质化学与利用;E-mail:shangsb@hotmail.com。

Synthesis and Antibacterial Activity of Diacylthiourea Derivatives Containing Acrylpimaryl Group

LI Jian1, RAO Xiao-ping1,2, SHANG Shi-bin1,2,3, GAO Yan-qing1   

  1. 1. Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.on Forest Chemical Engineering,SFA; Key Lab.of Biomass Energy and Material,Jiangsu Province, Nanjing 210042, China;2. Institute of New Technology of Forestry,CAF, Beijing 100091, China;3. Jiangsu Qianglin Biomass Energy Co.,Ltd., Liyang 213364, China
  • Received:2011-02-15 Revised:1900-01-01 Online:2011-10-30 Published:2011-10-30

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摘要： 松香与丙烯酸通过Diels-Alder双烯加成反应得到丙烯海松酸,丙烯海松酸经酰氯化和硫脲化合成了6个未见报道的双酰基硫脲衍生物,通过IR、 NMR、MS和元素分析等对产物进行了表征。初步的活性结果显示,丙烯海松双酰基硫脲衍生物对大肠杆菌和金黄色葡萄球菌都具有较好的抑制作用,特别是丙烯海松双-(3,5-二苯基)硫脲(4f)对大肠杆菌的抑菌活性比市售杀菌剂新洁尔灭高。

关键词: 松香, 丙烯海松酸, 双酰基硫脲, 抑菌活性

Abstract: Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction, then series of diacylthiourea derivatives containing acrylpimaryl group were synthesized. Their structures were characterized by IR, NMR, MS, and elemental analysis. The antibacterial activity of diacylthiourea derivatives against Gram-negative bacteria and Gram-positive bacteria were also investigated. The results indicated that diacylthiourea derivatives displayed extensive anti-bacterial activity against Gram-negative bacteria and Gram-positive bacteria. Especially, compared with commercial anti-bacterial agent(bromogeramine), compound 4f exhibits superior anti-bacterial activity against Escherichia coli(Gram-negative bacteria).

Key words: rosin, acrylpimaric acid, diacylthiourea, antibacterial activity

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