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林产化学与工业

林产化学与工业 ›› 2008, Vol. 28 ›› Issue (3): 91-93.

• 论文 • 上一篇    下一篇

2,3,4-三甲氧基苯甲酸的合成研究

徐浩1, 黄嘉玲2, 秦清1, 王光辉1, 陶林2   

  1. 1. 中国林业科学研究院, 林产化学工业研究所;国家林业局, 林产化学工程重点开放性实验室, 江苏, 南京, 210042;2. 南京龙源天然多酚合成厂, 江苏, 南京, 210032
  • 收稿日期:2008-01-17 修回日期:1900-01-01 出版日期:2008-06-30 发布日期:2008-06-30

Study on Synthesis of 2,3,4-Trimethoxybenzoic Acid

XU Hao1, HUANG Jia-ling2, QIN Qing1, WANG Guang-hui1, TAO Lin2   

  1. 1. Institute of Chemical Industry of Forest Products, CAF; Key and Open Lab.on Forest Chemical Engineering, SFA, Nanjing 210042, China;2. Nanjing Longyuan Natural Polyphenol Synthesis Factory, Nanjing 210032, China
  • Received:2008-01-17 Revised:1900-01-01 Online:2008-06-30 Published:2008-06-30

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摘要： 研究以焦性没食子酸衍生物2,3,4-三羟基苯甲酸为原料经过甲基化、水解、酸化和精制成2,3,4-三甲氧基苯甲酸.研究结果表明,甲基化的最佳条件:硫酸二甲酯与原料的物质的量比为4:1;催化剂用量为原料质量的5%.精制产品经IR和1H NMR确认了结构,产品质量用HPLC分析,纯度为99.54%.

关键词: 4-三羟基苯甲酸, 4-三甲氧基苯甲酸

Abstract: Preparation method of 2,3,4-trimethoxybenzoic acid is introduced, which was synthesized from 2,3,4-trihydroxybenzoic acid by methylation,hydrolysis,acidification and purification. The results showed that the optimal methylating condition was as follows: dosage ratio of dimethyl sulfate to 2,3,4-trihydroxybenzoic acid 4:1,dosage of calalyst 5%of 2,3,4-trihydroxybenzoic acid. The structure of the refined product was confirmed by IR and 1H NMR.The purity was 99.54% by HPLC.

Key words: 4-trimethoxybenzoic acid, 4-trihydroxybenzoic acid

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