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林产化学与工业

林产化学与工业 ›› 2003, Vol. 23 ›› Issue (3): 15-18.

• 研究报告 • 上一篇    下一篇

银杏叶聚戊烯醇联合化疗肿瘤的药效研究

王成章1, 沈兆邦1, 高凌2   

  1. 1. 中国林业科学研究院 林产化学工业研究所, 江苏 南京 210042;2. 江苏省肿瘤防治研究所, 江苏 南京 210009
  • 收稿日期:2003-01-07 修回日期:1900-01-01 出版日期:2003-09-30 发布日期:2003-09-30

PHARMACOLOGY OF POLYPRENOLS FROM GINKGO BILOBA L.LEAVES IN COMBINATION WITH CHEMOTHERAPEUTIC DRUGS ON TUMOR

WANG Cheng-zhang1, SHEN Zhao-bang1, GAO ling2   

  1. 1. Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China;2. Jiangsu Institute of Prophylactic and Therapeutic Tumor, Nanjing 210009, China
  • Received:2003-01-07 Revised:1900-01-01 Online:2003-09-30 Published:2003-09-30

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摘要： 研究了银杏叶聚戊烯醇(GP)联合化疗S180肿瘤的药效作用。从银杏叶中分离纯化聚戊烯醇,分别与阿霉素注射液(ADM)、氟脲嘧啶(5-Fu)、环磷酰胺(CTX)和顺铂(PDD)等化疗药联合用药,对S180荷瘤小鼠进行抑瘤实验,并与ADM、5-Fu、CTX和PDD单独用药比较。研究表明,聚戊烯醇与CTX、PDD、5-Fu联合化疗,对S180的抑瘤率分别从59.81%、43.06%、42.03%提高到70.56%、60.29%、63.45%;与ADM联合化疗,可使1.0mg/kg的ADM对S180的抑瘤率从50.93%提高到77.19%。研究结果表明,银杏叶聚戊烯醇具有明显的辅助化疗和减毒增效作用。

关键词: 银杏叶, 聚戊烯醇, 肿瘤辅助化疗, S180

Abstract: Pharmacology of polyprenols from Ginkgo biloba L.leaves(GP) in combination with chemotherapeutic drugs on tumor was studied.Polyprenols separated and purified from G.biloba L.leaves were administered in combination with adriamycin(ADM), 5-flauouracil(5-Fu), cyclophosphamide(CTX) and cisplatin(PDD) respectively, in contrasting with ADM, 5-Fu, CTX and PDD alone.Experiments were carried out on mouse with transplanted S180.Results show that for polyprenols in combination with CTX, PDD and 5-Fu, the inhibition of S180 nodule was raised from 59.81%, 43.06% and 42.03% to 70.56%, 60.29% and 63.45% respectively, in contrasting with their administration alone.For ADM in combination with polyprenols, 1.0 mg/kg ADM had raised the inhibition of S180 nodule from 50.93% to 77.19%.Results showed that polyprenols have a significant subsidiary effect on chemotherapy, along with reduced toxicity.

Key words: Ginkgo biloba L.leaves, polyprenols, tumor, subsidiary chemotherapy, S180

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