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林产化学与工业

林产化学与工业 ›› 2003, Vol. 23 ›› Issue (3): 11-14.

• 研究报告 • 上一篇    下一篇

高纯度天然右旋龙脑的制备研究

宋永芳, 罗嘉梁   

  1. 中国林业科学研究院 林产化学工业研究所, 江苏 南京 210042
  • 收稿日期:2002-10-11 修回日期:1900-01-01 出版日期:2003-09-30 发布日期:2003-09-30

STUDY ON PREPARATION OF HIGH-PURITY NATURAL d-BORNEOL

SONG Yong-fang, LUO Jia-liang   

  1. Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China
  • Received:2002-10-11 Revised:1900-01-01 Online:2003-09-30 Published:2003-09-30

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摘要： 以樟树[Cinnamomum glanduliferum(Wall)Nees]枝叶为原料经水蒸气蒸馏、升华得到70%～80%粗d-龙脑。为制备高纯度天然d-龙脑,进行了不同溶剂、不同溶剂量、结晶次数和结晶时间对d-龙脑纯度影响的研究。并用GC、GC/MS分析鉴定所制备的天然d-龙脑,用扫描电子显微镜观察d-龙脑结晶过程中晶体的结构变化。结果表明,汽油是结晶d-龙脑最好的溶剂,当物料比为1:1.7～2.0、结晶时间4d以上时,天然d-龙脑的纯度可达99%以上。精制天然d-龙脑产品的分析数据为:外观白色片状结晶,右旋龙脑含量>99%,旋光度[α]D20>+37°,熔点205～209℃,重金属<5×10-6,砷(As)<2×10-6。

关键词: 樟树, d-龙脑, 电子显微镜扫描, 结晶

Abstract: Crude d-borneol was obtained by water vapor distillation and sublimation from leaves of Cinnamomum glanduliferum (Wall) Nees.In order to prepare high purity d-borneol, experiments were carried out to investigate the effects of different solvent, solvent amount, times of crystallization and crystallizing time.High purity d-borneol was analyzed by GC and GC/MS, and crystal of d-borneol was examined by scanning electron microscopy(SEM).Results showed that gasoline is the best solvent for crystallizing d-borneol, purity of d-borneol product was over 99% using material:solvent ratio 1:1.7-2.0, and crystallizing time 4 days.Analytical data of the fine natural d-borneol products are:appearance of white slice crystals, d-borneol content>99%, optical rotation [α]D20>+37, melting point 205-209℃, heavy metals content <5 millionth and arsenide(As) content<2 millionth.

Key words: Cinnamomum glanduliferum(Wall) Nees, natural d-borneol, SEM, crystallization

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