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林产化学与工业

林产化学与工业 ›› 2012, Vol. 32 ›› Issue (6): 22-26.

• 1研究报告 • 上一篇    下一篇

聚N-异丙基丙烯酰胺-聚丙烯酸纳米胶囊的制备与载药性能研究

南静娅1, 陈莹1,2, 王春鹏1,2, 储富祥3   

  1. 1. 中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局林产化学工程重点开放性实验室;江苏省生物质能源与材料重点实验室, 江苏 南京 210042;2. 中国林业科学研究院林业新技术研究所, 北京 100091;3. 中国林业科学研究院, 北京 100091
  • 收稿日期:2012-09-19 修回日期:1900-01-01 出版日期:2013-12-30 发布日期:2013-12-30
  • 通讯作者: 陈 莹,副研究员,主要从事天然高分子纳米微粒的合成、表征和性能研究;E-mail:chenying80cn@yahoo.com.cn。

Preparation and Characterization of Poly (N-isopropylacrylamide)-poly (acrylic acid) Nanocapules

NAN Jing-ya1, CHEN Ying1,2, WANG Chun-peng1,2, CHU Fu-xiang3   

  1. 1. Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.of Forest Chemical Engineering,SFA;Key Lab.of Biomass Energy and Material,Jiangsu Province,Nanjing 210042, China;2. Institute of New Technology of Forestry,CAF, Beijing 100091, China;3. Chinese Academy of Forestry, Beijing 100091, China
  • Received:2012-09-19 Revised:1900-01-01 Online:2013-12-30 Published:2013-12-30

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摘要： 以羟丙基纤维素-聚丙烯酸(HPC-PAA)高分子复合物微粒为模板,通过自由基聚合反应在模板表面聚合单体N-异丙基丙烯酰胺(NIPAm),形成HPC-PAA-PNIPAm复合物纳米微粒,平均粒径约为130nm。调节体系的pH值至8.0去除HPC模板后,获得中空结构的PNIPAm-PAA纳米胶囊,粒径约为500nm。以盐酸阿霉素(Dox)作为模型药物,考察了PNIPAm-PAA纳米胶囊作为药物载体的相关性能。研究表明:PNIPAm-PAA纳米胶囊和Dox分子通过正负电荷的相互吸引实现有效结合,载药量高达130 %;同时,载药纳米胶囊表现出很好的药物缓释效果。

关键词: 聚N-异丙基丙烯酰胺, 聚丙烯酸, 纳米胶囊, 药物载体

Abstract: In this study, a novel approach has been developed for the preparation of poly (N-isopropylacrylamide)-poly (acrylic acid) (PNIPAm-PAA) nanocapules. In the first instance, the core-shell nanoparticles, which diameter was about 130 nm, were synthesized by precipitation polymerization with hydropropylcellulose-poly (acrylic acid) (HPC-PAA) particles as the core and the cross-linked PNIPAm as the shell. After the selective removal of HPC from the particles by adjusting the pH of solution to 8.0, hollow PNIPAm-PAA nanocapules were obtained and the average diameter was 500 nm. Furthermore, the loading and releasing behaviors of PNIPAm-PAA nanocapules were evaluated in mild condition by using anti-cancer drug Doxorubicin hydrochloride (Dox) as a hydrophilic model drug. It showed a super-high drug loading capacity of about 130 %, and a sustained-release characteristic under the physiological pH and temperature.

Key words: poly (N-isopropylacrylamide), poly (acrylic acid), nanocapules, drug carriern

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