蒎酸基双硫脲类化合物的合成及生物活性研究

doi:10.3969/j.issn.0253-2417.2013.01.007

›› 2013, Vol. 33 ›› Issue (1): 37-44.doi: 10.3969/j.issn.0253-2417.2013.01.007

• 1研究报告 • Previous Articles Next Articles

Synthesis and Biological Activities of Pinic Acid-based Dithioureas

MA Chang-hua¹, CEN Bo¹, DUAN Wen-gui¹, MA Xian-li^1,2, QIN Shan¹, LIN Gui-shan¹, QIN Yu-ning¹

1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;2. College of Pharmacy, Guilin Medical University, Guilin 541004, China

Received:2012-02-27 Revised:1900-01-01 Online:2013-02-28 Published:2013-02-28

Abstract

Abstract: Pinic acid was prepared via oxidation and bromoform reactions using α-pinene as starting material, and it was converted into dichloride. Then, pinic acid-based diisothiocyanates were synthesized by the reaction of pinic acid dichloride with potassim thiocyanate, followed by N-acylation reaction of pinic acid-based diisothiocyanates with phenyl amines to afford twelve novel pinic acid-based dithioureas. The structures of the target compounds were characterized by means of IR, ¹H NMR, ¹³C NMR, MS, and elemental analysis. The preliminary bioassay showed that the title compounds exhibited a certain herbicidal activity, fungicidal activity, and plant growth regulating activity. Compound E1 displayed growth inhibition activity of 66.6% against root of rape (Brassica campestris) at the concentration of 100 mg/L (B-class activity level).

Key words: α-pinene, pinic acid, pinic acid-based dithiourea, synthesis, bioactivity

CLC Number:

TQ35

MA Chang-hua;CEN Bo;DUAN Wen-gui;MA Xian-li;QIN Shan;LIN Gui-shan;QIN Yu-ning. Synthesis and Biological Activities of Pinic Acid-based Dithioureas[J]. , 2013, 33(1): 37-44.

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Synthesis and Biological Activities of Pinic Acid-based Dithioureas

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