雷公藤化学成分及其热稳定性研究

doi:10.3969/j.issn.0253-2417.2017.02.009

Abstract

Abstract: Seven compounds were isolated from the radix of Tripterygium wilfordii Hook. f.. Their structures were identified as β-sitosterol(1), syringaldehyde(2), tripdiolide(3), β-hydroxypropiovanillone(4), 5, 5'-dimethoxylariciresinol(5), neociwujiaphenol(6) and wilfordoside A(7). Compounds 2, 4, 5 and 6 were isolated from genus of T. wilfordii for the first time. Thermal decomposing curves of compounds 3, 6, wilforlide A and demethylzeylasteral were obtained in the nitrogen atmosphere by TG-DTG and DTA techniques. The results indicated that the four tested compounds should be stable under 200 ℃. This study could lay a foundation for the quality standard and roasting mechanism of T. wilfordii.

Key words: Tripterygium wilfordii, chemical constituent, thermal stability

CLC Number:

TQ35

LIU Jianqun, WU Qiushan, YU Zhaofen. Chemical Constituents from Tripterygium wilfordii Hook. f. and Their Thermal Stability[J]. Chemistry and Industry of Forest Products, 2017, 37(2): 72-78.

References

[1] 熊雪婷,许碧莲.Wnt信号通路在类风湿性关节炎发病机制中的研究进展[J].中国药理学通报,2014,30(1):13-16. XIONG X T,XU B L.Research progress of Wnt signaling pathway in pathogenesis of rheumatoid arthritis[J].Chinese Pharmacological Bulletin,2014,30(1):13-16.
[2] 万欢.中西药物治疗类风湿性关节炎的研究进展[J].实用心脑肺血管病杂志,2010,18(9):1379-1381. WAN H.Research progress of traditional Chinese and western medicine in rheumatoid arthritis[J].Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2010,18(9):1379-1381.
[3] 郭艳红,谭垦.雷公藤的毒性及其研究概况[J].中药材,2007,30(1):112-117. GUO Y H,TAN K.Toxicity and research survey of Tripterygium wilfordii Hook[J].Journal of Chinese Medicinal Materials,2007,30(1):112-117.
[4] 李建友,夏素霞,宋少江.雷公藤二萜类化学成分及在研新药的研究进展[J].沈阳药科大学学报,2012,29(11):901-908. LI J Y,XIA S X,SONG S J.Research progress of diterpenoids from Tripterygium and the study on new drugs[J].Journal of Shenyang Pharmaceutical University,2012,29(11):901-908.
[5] 张茹萍,何昱,石森林,等.雷公藤药材中6种有效成分以及总二萜内酯、总生物碱、总三萜的含量测定[J].中华中医药杂志,2013,28(1):224-229. ZHANG R P,HE Y,SHI S L,et al.Determination of six effective components,total diterpenoids,total alkaloids and total triterpenes in Tripterygium wilfordii Hook.f[J].China Journal of Traditional Chinese Medicine and Pharmacy,2013,28(1):224-229.
[6] 田洋,郝淑娟,马跃平,等.雷公藤根化学成分的分离与鉴定[J].沈阳药科大学学报,2010,27(9):715-718,723. TIAN Y,HAO S J,MA Y P,et al.Isolation and identification of chemical constituents of roots of Tripterygium wilfordii Hook.f[J].Journal of Shenyang Pharmaceutical University,2010,27(9):715-718,723.
[7] 林绥,李援朝,刘子皎,等.雷公藤中木脂素类成分的研究[J].中国药学杂志,2000,35(4):15-16. LIN S,LI Y C,LIU Z J,et al.Studies on lignans constituents of Tripterygium wilfordine[J].Chinese Pharmaceutical Journal,2000,35(4):15-16.
[8] 刘泽洲,许可嘉,张天娇,等.雷公藤甲素诱导小鼠急性肝损伤的形态学研究[J].现代生物医学进展,2015,15(17):3207-3211. LIU Z Z,XU K J,ZHANG T J,et al.The morphological study on acute liver injury of mice induced by triptolide[J].Progress in Modern Biomedicine,2015,15(17):3207-3211.
[9] 李春杏,李太生,朱珠,等.雷公藤抗炎免疫调节活性单体的研究进展[J].中国中药杂志,2014,39(21):4159-4164. LI C X,LI T S,ZHU Z,et al.Advance in studies on anti-inflammatory and immunoregulatory monomers of Tripterygium wilfordii[J].China Journal of Chinese Materia Medica,2014,39(21):4159-4164.
[10] 许羚,胡,丁晓霜,等.雷公藤红素体内与体外急性毒性试验结果的比较[J].环境与职业医学,2015,32(6):535-538,548. XU L, HU Y,DING X S,et al.Comparison on acute toxicity of celastrol derived from in vivo and in vitro[J].Journal of Environmental & Occupational Medicine,2015,32(6):535-538,548.
[11] 刘建群,张国华,高俊博.烘箱煨制雷公藤药效毒性及成分变化研究[J].亚太传统医药,2015,11(10):7-9. LIU J Q,ZHANG G H,GAO J B.Effect of oven heating processing on toxicity,efficacy and constituents of Tripteryginum wilfordii[J].Asia-Pacific Traditional Medicine,2015,11(10):7-9.
[12] 刘建群,张国华,高俊博.一种雷公藤的炮制方法:CN104306426A[P].2015-01-28. LIU J Q,ZHANG G H,GAO J B.A processing method of Tripteryginum wilfordii:CN104306426A[P].2015-01-28.
[13] LEE S J,KIM H M,LEE J M,et al.Artemisterol,a new steryl ester from the whole plant of Artemisia apiacea[J].Journal of Asian Natural Products Research,2008,10(4):281-283.
[14] 张怡评,韩顺风,方华,等.互花米草化学成分研究[J].中国海洋药物,2016,35(1):55-59. ZHANG Y P,HAN S F,FANG H,et al.Study on the chemical constituents of Spartina alterni flora Loisel[J].Chinese Journal of Marine Drugs,2016,35(1):55-59.
[15] 林绥,于贤勇,阙慧卿,等.雷公藤中的二萜内酯类成分[J].药学学报,2005,40(7):632-635. LIN S,YU X Y,QUE H Q,et al.Diterpenes consitutents of Tripteryginum wilfordii[J].Acta Pharmaceutica Sinica,2005,40(7):632-635.
[16] 罗川,张万年,杨美灵.米邦塔仙人掌化学成分研究[J].天然产物研究与开发,2011,23(6):1038-1040. LUO C,ZHANG W N,YANG M L.Chemical constituents of Opuntia milpa Alta Haw[J].Natural Product Research and Development,2011,23(6):1038-1040.
[17] YUASA K,IDE T,OTSUKI H,et al.Lignan and neolignan glycosides from stems of Alangium premnifolium[J].Phytochemistry,1997,45(3):611-615.
[18] 吴立军,阮丽军,郑健,等.刺五加茎叶化学成分研究[J].药学学报,1999,34(11):839-841. WU L J,RUAN L J,ZHENG J,et al.Studies on chemical constituents from Acanthopanax senticosus(Rupr.ETMASIM) Harms[J].Acta Pharmaceutica Sinica,1999,34(11):839-841.
[19] LI H M,WAN D W,LI R T.New abietane-type diterpene glycosides from the roots of Tripterygium wilfordii[J]. Journal of Asian Natural Products Research,2015,17(7):761-766.

Chemical Constituents from Tripterygium wilfordii Hook. f. and Their Thermal Stability

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