栀子多糖的抗肿瘤活性研究

›› 2002, Vol. 22 ›› Issue (04): 67-70.

• 研究报告 • Previous Articles Next Articles

ANTI-TUMOR ACTIVITY OF GARDENIA JASMINOIDES EILLS POLYSACCHARIDE

SHI Ruo-fu^1,2, LI Da-li², TIAN Chun-yu¹, WANG Guan-lin³, FANG Hong-jun³

1. Chemical Institute of Dalian University of Technology, Dalian 116012, China;2. Chemical Engineering College, Najing University of Science and Technology, Nanjing 210094, China;3. Life Science Institute of Liaoning Normal University, Dalian 116029, China

Received:2002-01-15 Revised:1900-01-01 Online:2002-12-30 Published:2002-12-30

Abstract

Abstract: Effect of Gardenia jasminoides Eills polysaccharide (GJEP) on three kinds of tumor cells were studied with three different methods respectively.Results show that GJEP has wide ranging anti tumor activity.Effect of GJEP on tumor induced by Agrobacterium tumefaciens C58 was determined with potato chips method,and the restrain ratio of 1.258 mg/mL GJEP is 68.14% ;Effect of GJEP on erythroleukemia was determined with MTT method,and no poisonous dose is 0.4 μg/mL,low poiso nous dose is 14.33 μg/mL and median lethal dose is 62.61 μg/mL.Restrain ratio of 100 μg/mL GJEP on erythroleukemia is 63.2% ;Restrain ratio of GJEP on ascites liver cancer Hca-f tumor in BALB-c mice was determined with weight tumor method,which shows that the result of ig is better than that of ip,and restrain ratio of 500 mg/(kg·day) GJEP (ig) on ascites liver cancer Hca f tumor in BALB c mice is 49%.

Key words: Gardenia jasminoides Eills, polysaccharide, anti-tumor activity

CLC Number:

SHI Ruo-fu;LI Da-li;TIAN Chun-yu;WANG Guan-lin;FANG Hong-jun. ANTI-TUMOR ACTIVITY OF GARDENIA JASMINOIDES EILLS POLYSACCHARIDE[J]. , 2002, 22(04): 67-70.

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ANTI-TUMOR ACTIVITY OF GARDENIA JASMINOIDES EILLS POLYSACCHARIDE

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