4-异丙基-1,3-环己二烯酸酯衍生物的合成及其抑菌性能研究

›› 2011, Vol. 31 ›› Issue (6): 15-19.

• 研究报告 • Previous Articles Next Articles

Synthesis and Antibacterial Activity of Dihydrocumates

GAO Yan-qing¹, WANG Dan^1,2, SHANG Shi-bin^1,2,3, LI Jian¹

1. Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.on Forest Chemical Engineering,SFA;Key Lab.of Biomass Energy and Material,Jiangsu Province, Nanjing 210042, China;2. Institute of New Technology of Forestry,CAF, Beijing 100091, China;3. Jiangsu Qianglin Biomass Energy Co.,Ltd., Liyang 213364, China

Received:2011-02-16 Revised:1900-01-01 Online:2011-12-30 Published:2011-12-30

Abstract

Abstract: Nopinic acid was synthesized using β-pinene as raw material and potassium permanganate as oxidant. After the dehydration of aqueous sulfuric acid, dihydrocumic acid was obtained. Fourteen esters were prepared by reactions of alcohols with dihydrocumic acid chloride. The preparation conditions were discussed and the structure of products were confirmed by IR, ¹H NMR and MS. The antibacterial activity of products was tested through inhibition zone. Compared with the standard compound bromogeramine which diameter of inhibition zone is 9.67 mm, the compounds exhibit an excellent anti-bacterial activity against Escherichia coli(Gram-negative bacteria) except compounds 5f and 5g.

Key words: β-pinene, nopinic acid, dihydrocumic acid, ester derivatives, antibacterial activity

CLC Number:

TQ351

GAO Yan-qing;WANG Dan;SHANG Shi-bin;;LI Jian. Synthesis and Antibacterial Activity of Dihydrocumates[J]. , 2011, 31(6): 15-19.

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Synthesis and Antibacterial Activity of Dihydrocumates

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